Expression and function of SHP-2 of thymocytes in ?-ray irradiation induced leukemia in mice
- VernacularTitle:?线诱发的白血病小鼠胸腺细胞中SHP-2表达及功能的研究
- Author:
Dingde HUANG
;
Qi CHEN
;
Lin HAN
;
Jianming CAI
;
- Publication Type:Journal Article
- Keywords:
radiation carcinogenesis;
signal transduction;
protein tyrosine phosphatase;
BALB/c mouse;
leukemia
- From:Journal of Third Military Medical University
2003;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and function of SH2 domain containing protein tyrosine phosphatase SHP 2 of thymocytes in ? ray irradiation induced leukemia in mice. Methods BALB/c mice were divided into canceration group, non canceration group, and control group. The expression, level of tyrosine phosphorylation, and enzyme catalytic activity of SHP 2 in thymocytes were detected by Western blotting, immunoprecipitation, and biochemical method. Results There was obvious correlation among the expression, level of tyrosine phosphorylation, and enzyme catalytic activity of SHP 2, which were significantly higher in the canceration group than those in the non canceration group and the control group ( P
