Influence factors of the release rate of benorilate from sustained-release matrix tablets
- VernacularTitle:贝诺酯缓释骨架片释药速率影响因素实验研究
- Author:
Daiyong CHEN
;
Zhihe ZANG
;
Wanqing YANG
;
Miao ZHAO
;
- Publication Type:Journal Article
- Keywords:
benorilate;
sustained release tablet;
hydroxypropylmethylcellulose;
release rate
- From:Journal of Third Military Medical University
2003;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence factors of the release rate of benorilate from sustained release matrix tablets. Methods The matrix tablets of benorilate were prepared by using hydroxypropylmethylcellulose (HPMC) as the matrix material. The effects of the contents of HPMC, polyvinyl pyrrolidone (PVP), and microcrystaline cellulose (MCC), and the method of preparation on in vitro drug release were studied by evaluating the n value in the Peppas equation. Results The increasing HPMC content led to decrease of benorilate release. However, PVP and MCC used in this experiment accelerated the benorilate release from the tablets. The drug released from the tablet prepared by dry method was faster than that by wet method. Conclusion The contents of HPMC, PVP, and MCC, especially HPMC, have effects on the release rate of benorilate, but the two preparation methods have less effect.
