Prediction of HLA-A~*0201-restricted CTL epitopes in SARS-CoV E protein
- VernacularTitle:SARS冠状病毒E蛋白HLA-A~*0201限制性CTL表位的预测
- Author:
Qing WANG
;
Yuzhang WU
;
- Publication Type:Journal Article
- Keywords:
E protein;
HLA;
CTL epitope;
supermotif;
quantitative matrix
- From:Journal of Third Military Medical University
2002;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To predict the HLA A *0201 restricted CTL epitopes (nonamers) in SARS coronavirus (SARS CoV) E protein. Methods The CTL epitopes of E protein were predicted by using supermotif method combined with quantitative matrix method. Results Thirteen HLA A *0201 restricted CTL epitope candidates were predicted in SARS CoV E protein. Conclusion The prediction of the CTL epitopes in SARS CoV E protein will benefit the identification of CTL epitopes by experiment. Those results are of importance for immune recognition and vaccine design for SARS CoV.
