Combined recombinant human growth hormoneand fibrin glue accelerate wound healing of intestinal anastomosis in abdominal sepsis:A dynamic study
- VernacularTitle:生长激素、纤维蛋白胶促进腹腔感染大鼠肠吻合口愈合的动态研究
- Author:
Yousheng LI
;
Yang BAO
;
Tao JIANG
;
Jieshou LI
;
- Publication Type:Journal Article
- Keywords:
Wound healing;
Sepsis;
Growth hormone;
Fibrin glue
- From:
Parenteral & Enteral Nutrition
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To determine whether administration of growth hormone and fibrin glue could attenuate the inhibitory effects of sepsis on wound healing of intestinal anastomosis in rats. Methods: Antimesenteric transverse enterotomy of 4 mm was performed, a second laparotomy was subsequently performed after 24 hours, 6 cm of the intestine in the middle of the fistula segment was resected. An end-to-end single layer anastomosis was constructed using 4 inverted interrupted 6/0 polypropylene sutures. After anastomosis, the animals were divided into three groups.In control group, the rats had a sutured anastomosis;in fibrin glue(FG) group, the rats had a sutured anastomosis and fibrin glue; and in the FG/GH group, the rats had a sutured anastomosis,fibrin glueand growth hormone.Growth hormone of 3.0 U/(kg?d) was injected subcutaneously every 24 hours for 14 days. The anastomotic bursting pressureand breaking strength, hydroxyproline contentand histologywere measured as indicators of wound healing. Results: The breaking strengthand bursting pressureof intestinal anastomosis were increased at 12 th postoperatively and lasted for 5 days in FG group, and they were increased and lasted for 14 days in FG/GH group. Conclusions: Both fibrin glueand growth hormone can improve wound healing of intestinal anastomosis, and they had the effect of congruential sequence.
