Changes in the GH-IGF-IGFBP axis in traumatic and septic patients and its clinical significance
- VernacularTitle:创伤及感染时GH-IGF-IGFBP轴的变化及其临床意义
- Author:
Xulin WANG
;
Weiqin LI
;
- Publication Type:Journal Article
- Keywords:
Trauma;
sepsis;
GH;
IGF;
IGFBP
- From:
Parenteral & Enteral Nutrition
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Increased catabolism, including reduced protein synthesis rates and increased protein degration rates, is common in patient with trauma and sepsis. There has been a long time search in how to reverse the increased catabolism. Besides nutritional support, people hope manipulation of anti catabolism hormone might reverse or at least ameliorate catabolism. Recent researches indicate that the GH IGF IGFBP axis plays a crucial part in regulating the metabolism of muscle protein on both basal and stress condition. This article aims to review the changes in GH IGF IGFBP axis and its clinical significance associated with trauma and sepsis.
