Effects of puerarin on the levels of PGI_2 and TXA_2 in plasma of rats with hyperlipidemia
- VernacularTitle:葛根素对高脂血症大鼠脂质代谢及血浆PGI_2、TXA_2水平的影响
- Author:
Haiyan LIU
;
Yuangang SHI
;
- Publication Type:Journal Article
- Keywords:
hyperlipidemia;
puerarin;
PGI 2;
TXA 2
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of puerarin on levels of thromboxane A 2 (TXA 2) and prostaglandin I 2 (PGI 2) in plasma of rats with hyperlipidemia. Methods A total of 48 Wistar juvenile rats were randomly divided into four groups: normal diet, high fat and high cholesterol diet (HFD), HFD supplemented respectively with 1 g/kg puerarin (puerarin group Ⅰ) or 2 g/kg puerarin (puerarin group Ⅱ). After eight weeks of feeding, the rats were sacrificed for detection of the levels of lipid, TXA 2, and PGI 2. Results The blood triglycerol, total cholesterol, LDL C, TXA 2, and TXA 2/PGI 2 were significantly lower in puetarin Ⅰ and puerarin Ⅱ groups than those in HFD group, but the concentration of HDL C was significantly increased in the supplemented group( F =109 163, P =0 000; P
