Correlation between the VEGF-C and VEGF-D expressions and the retroperitoneal and inguinal lymph node metastasis in human epithelial ovarian carcinoma
- VernacularTitle:血管内皮生长因子C、D在上皮性卵巢癌的表达及与腹股沟和腹膜后淋巴结转移的关系
- Author:
Yuzhen WANG
;
Zhiqing LIANG
;
Ling LONG
;
Dan WANG
;
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor C;
vascular endothelial growth factor D;
immunohistochemistry;
ovarian carcinoma;
lymphangiogenesis;
lymphatic metastasis
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the expressions of vascular endothelial growth factor C (VEGF C) and vascular endothelial growth factor D (VEGF D) and the lymph node metastasis of groin and retroperitoneum in human epithelial ovarian carcinoma. Methods The expressions of VEGF C and VEGF D in benign, borderline, and malignant epithelial ovarian tumors were detected by immunohistochemistry and light microscopy. Results The expressions of VEGF C and VEGF D were found in benign, borderline, and malignant epithelial ovarian tumors. The expressions of VEGF C and VEGF D in ovarian carcinomas were significantly higher than those in benign and borderline ovarian tumors. The expression levels of VEGF C and VEGF D were correlated with peritoneal metastasis, lymph node metastasis of groin and retroperitoneum, and clinical stage, but not with distant metastasis, histology type, histological grade, and age. Conclusion Up regulation of VEGF C and VEGF D in epithelial ovarian carcinoma is advantageous to lymph node metastasis. This process may probably be correlated with lymphangiogenesis in tumors.
