Effects of flunarizine on the intracellular free calcium concentration in acute intracerebral hemorrhage in rats
- VernacularTitle:氟桂利嗪对大鼠脑出血后脑细胞内游离钙的影响
- Author:
Ling LI
;
Kangning CHEN
;
Fuming CHEN
;
- Publication Type:Journal Article
- Keywords:
flunarizine;
Ca 2+;
experimental intracerebral hemorrhage;
Fura-2/AM
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of flunarizine on the intracerebral hemorrhage (ICH) of Wistar rats at different time points. Methods An ICH rat model was established by collagenase. The concentrations of intracellular free Ca 2+ at different time points after ICH were determined by the fluorescence detector with an indicator, Fura 2/AM. The effects of flunarizine on the concentrations at different time points were also observed. Results The concentration of intracellular free Ca 2+ began to increase at 0.5 h, increased significantly at 6 h, and peaked at 24 h (about 4 folds as high as that before hemorrhage), but began to decrease at 72 h after acute intracerebral hemorrhage. Flunarizine decreased the concentration of intracellular free Ca 2+ significantly ( P
