Preparation of gliclazide-hydroxypropyl-?-cyclodextrin inclusion complexes
- VernacularTitle:格列齐特-羟丙基-?-环糊精包合物的制备
- Author:
Jing HE
;
Zhangyang WANG
;
Songqing LIU
;
- Publication Type:Journal Article
- Keywords:
gliclazide;
hydroxypropyl-?-cyclodextrin;
inclusion complex;
solubility
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare gliclazide (GZ) hydroxypropyl ? cyclodextrin (HP ? CD) inclusion complexes in order to enhance its aqueous solubility. Methods Inclusion complexes, prepared using 3 different methods of spray drying, freeze drying, and grinding, were identified by phase solubility analysis, infrared spectrophotometry, thermal analysis, and determination of the limited ammonium concentration. Results The HP ? CD inclusion complexes could be prepared by using the 3 different methods. The ratio of host/guest molecules was 1∶1. Ammonium residues were detected in inclusion complexes prepared by the freeze dried method. Conclusion The inclusion complexes can be prepared by the spray drying and grinding methods. The solubility of gliclazide can be significantly increased in the inclusion complexes.
