Roles of bacterial infection in acute lung injury and acute respiratory distress syndrome
- VernacularTitle:细菌感染在急性肺损伤/急性呼吸窘迫综合征中的作用
- Author:
Xiaoming CHENG
;
Yanqi ZHANG
;
Guisheng QIAN
;
- Publication Type:Journal Article
- Keywords:
bacterial infection;
acute lung injury;
acute respiratory distress syndrome;
systemic inflammatory response syndrome;
multiple organ dysfunction syndrome
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the roles of bacterial infection in the pathogenesis and progression of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Methods The clinical data of 604 patients with ALI or ARDS hospitalized from April 1991 to March 2001 were analyzed. Results (1) The cause of direct lung injury was predominantly ascribed to lung infection, whereas indirect lung injury was due to sepsis. (2) The gram positive cocci (50.76%) and gram negative bacilli (40.15%) in the isolated pathogenic bacteria from patients were approximately similar. Furthermore, Staphylococcus aureus and Pseudomonas aeruginosa were the first and second pathogenic bacteria, respectively. (3) The incidences of ALI and ARDS in infected patients significantly increased with the grade elevation of systemic inflammatory response syndrome (SIRS) ( P
