Small intestinal absorption manners of glimepiride in rats
- VernacularTitle:格列美脲大鼠小肠吸收的研究
- Author:
Rong ZHANG
;
Laichun LU
;
Xuehua JIANG
;
- Publication Type:Journal Article
- Keywords:
glimepiride;
small intestinal absorption;
passive diffusion;
high performance liquid chromatography
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the small intestinal absorption patterns of glimepiride in rats. Methods A rat model of small intestinal absorption in vivo was employed in this study. The small intestinal absorption rate of glimepiride was detected by high performance liquid chromatography. Results At the low and high concentrations of glimepiride, the average small intestinal absorption rates were 0.233 6 h -1 and 0.217 8 h -1 , respectively. Conclusion The small intestinal absorption pattern of glimepiride might be passive diffusion.
