Effects of PDLLA/HA/DBM biomaterials on the activity of osteoblast proliferation
- VernacularTitle:PDLLA/HA/DBM复合生物材料对成骨细胞增殖活性的影响
- Author:
Qiaonan GUO
;
Jianhua ZHAO
;
Jiayou LU
;
- Publication Type:Journal Article
- Keywords:
osteoblast;
cell culture;
biomaterial;
cell proliferation
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of PDLLA/HA/DBMV biomaterials on cell proliferation by comparison of polyactic acid (PDLLA) and decalcified bone matrix (DBM) so as to evaluate the biocompatibility of the biomaterials at the cell level. Methods The isolated third generation human fetal osteoblasts (suspension, 3.5?10 5/ml) were inoculated onto the biomaterials of PDLLAHA/DBM, PDLLA, and DBM for 1, 2, 3, 5, and 7 d. Proliferation rates of cells on different materials were determined by flow cytometry. Results The osteoblast proliferation rate on PDLLA/HA/DBM was higher than that on PLA and DBM. Conclusion PDLLA/HA/DBM is compatible for the growth of osteoblasts.
