Effects of dopaminergic neurons differentiated from mesencephalic NSCs induced by transplantation on treatment of Parkinson's disease in rats
- VernacularTitle:移植诱导中脑NSCs分化的多巴胺能神经元对PD大鼠治疗作用的实验研究
- Author:
Xiaoqiang YU
;
Huaizhen RUAN
;
Wenqin CAI
;
Xiaotang FAN
;
Zhongxiang YAO
;
Hui YANG
;
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
neural stem cell;
neural transplantation
- From:Journal of Third Military Medical University
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutical effect of dopaminergic neurons induced by transplantation on Parkinson's disease (PD) rats. Methods Mesencephalic nerve stem cells (NSCs) were induced by striatal extracts to differentiate into tyroxine hydroxylase (TH) positive dopaminergic neurons. The differentiated cells were transplanted into the striatum of PD rats. The survived cells were detected by TH immunocytochemical staining. The therapeutical effect was observed using apomorphine induced rotation. Results Mesencephalic NSCs could be induced to differentiate into dopaminergic neurons which could survive in the host for long time after cell transplantation, and could improve the apomorphine induced rotation. Conclusion The induced mesencephalic NSCs have the obvious therapeutical effect on PD.
