Myocardium ischemic preconditioning:today and tomorrow
- VernacularTitle:心肌缺血预适应的研究现状及其展望
- Author:
Zhinong WANG
;
Baoren ZHANG
;
- Publication Type:Journal Article
- Keywords:
ischemic preconditioning;
myocardium;
apoptosis;
cardiopulmonary bypass
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic preconditioning (IPC), as a powerful endogenous cardioprotective adaptation, has brought a new research field for prevention and inhibition of myocardial ischemic reperfusion injury. This article is to evaluate the current information regarding the process of IPC and the possible mechanisms involved, with special attention paid to the protein kinase C and mitochondrial ATP sensitive potassium channels. The article also pointed out that the future role of IPC in clinical practice would strongly depend on the exact cellular and molecular mechanism underlying the IPC phenomenon. Pharmacological preconditioning seems to represent a perspective role of IPC in clinical practice.
