A Meta-analysis of somatostatin analogues in treatment of Graves ophthalmopathy
- VernacularTitle:生长抑素类似物对Graves眼病治疗作用的Meta分析
- Author:
Xiang LI
;
Mingjun GU
;
Yumei SHEN
;
Zhimin LIU
;
- Publication Type:Journal Article
- Keywords:
somatostatin analogues;
Graves ophthalmopathy;
proptosis;
glucocorticoid;
Meta analysis
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine whether somatostatin analogous(SSAs) have effect on Graves ophthalmopathy and to compare its effects with that of glucocorticoid.Methods: Both a computer aided search of MEDLINE and Chinese Biological Medicine disc and an intensive search by hand were conducted to identify all controlled studies assessing the effect of SSAs on Graves ophthalmopathy.Results: Five studies were finally included.Three of them found SSAs to be significantly more effective than placebo;2 of them found SSAs to be able to reduce proptosis; 2 of them found SSAs to be equally effctive as glucocorticoid.The pooled OR, pooled mean difference, pooled OR were 0.070.02,0.23],-1.47 -2.10,-0.84] and 0.95 0.25,3.59] respectively.Conclusion: This Meta analysis demonstrates that SSAs are effective in treatment of Graves ophthalmopathy and in reduction of proptosis, and it is equally effctive as glucocorticoid.
