Progress in Cdr1p and Cdr2p proteins mediating multidrug resistance in Candida albicans
- VernacularTitle:白念珠菌多药耐药蛋白Cdr1p和Cdr2p的研究进展
- Author:
Xinming JIA
;
Pinghui GAO
;
Yongbing CAO
;
Yuanying JIANG
;
- Publication Type:Journal Article
- Keywords:
ATP binding cassette transporter;
Candida albicans;
multidrug resistance;
Cdr1p;
Cdr2p
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
ATP binding cassette transporter (ABCT),a membrane transporting protein existing in mammalian, bacterial, fungal and many other types of cells, is correlated with multidrug resistance in many cells. To date 10 ABCT have been described in Candida albicans , but only CDR1 and CDR2 genes were associated with multidrug resistance. Moreover, their encoding proteins Cdr1p and Cdr2p have many functions such as efflux pump and phospholipid translocator. The progress in the study of Cdr1p and Cdr2p proteins mediating multidrug resistance in Candida albicans was summarized in the paper.
