Correlation between expression of platelet membrane glycoproteins and hyperviscosity syndrome
- VernacularTitle:高黏滞综合征与血小板膜糖蛋白表达的关系
- Author:
Zimin LU
;
Qixi ZHANG
;
Bing XIU
;
Jinying WU
;
Weiping ZHENG
;
- Publication Type:Journal Article
- Keywords:
hyperviscosity syndrome;
flow cytometry;
platelet membrane glycoproteins
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between hyperviscosity syndrome(HVS) and platelet membrane glycoproteins(GP) sub group changes.Methods: CD62P,CD63,CD31 and CD41 were measured by flow cytometry(FCM). The hemorrheoloic parameters of HVS patients were compared with those of normal aged group and normal young group.Results:(1)The CD62P,CD63 and CD31 of aged and young HVS patients before therapy were obviously higher than those of the normal aged group and normal young group.(2)Combined measurement could improve the detecting positive rate of HVS patients up to 92% 100%, with the sensitivity being 95.3%.(3)Bamyl decreased CD62P,CD63 and CD31,which was obviously correlated with ?b and ?p. Conclusion:The alteration of platelet membrane GP positive expression may be a parameter for early diagnosis and clinical outcome observation.
