Changes of somatostatin and acetylcholine contents in vascular dementia rats
- VernacularTitle:血管性痴呆大鼠脑中生长抑素和乙酰胆碱含量的变化
- Author:
Lili ZHANG
;
Jingzhou WANG
;
Wensheng LIU
;
Mane CHEN
;
- Publication Type:Journal Article
- Keywords:
vascular dementia;
somatostatin;
acetylcholine;
huperzine A
- From:Journal of Third Military Medical University
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes and significance of somatostatin (SS) and acetylcholine (Ach) contents in vascular dementia rats. Methods Model of vascular dementia rats was established. Active avoidance responase (AAR) ratio was used as the index for the judgement of the learning and memory abilities of vascular dementia rats. The SS and Ach contents in different cerebral sections of rats with and without intervention of huperzine A were determined by radioimmunoassay. Results A remarkable decrease in SS and Ach contents was found in vascular dementia rats, which could be reversed by intervention of huperzine A. Conclusion The decreased SS content in cerebrum after ischemia is related with vascular dementia. SS may be involved in the pathological process of vascular dementia through the mutual regulation with Ach.
