Tissue distribution of strychnos nux-vomica alkaloids in rats
- VernacularTitle:马钱子生物碱在大鼠体内的组织分布
- Author:
Baochang CAI
;
Xiaoyue XU
;
Yang PAN
;
Tianshan WANG
;
Yanchao LI
;
- Publication Type:Journal Article
- Keywords:
strychnos nux vomica;
alkaloid;
tissue distribution
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the tissue distribution of strychnos nux vomica alkaloids in rats. METHODS Rats were given strychnos nux vomica alkaloids intravenously and strychnine(S), brucine(B), strychnine N oxide(SNO), brucine N oxide(BNO) in every tissue was determined by HPLC timely. RESULTS The concentration of S, B, SNO and BNO were high in brain and spinal marrow. CONCLUSION S, B, SNO and BNO all have the ability to permeate blood brain barrier.
