Effects of desulfated and poly-sulfated heparin derivatives on rat mast cell degranulation
- VernacularTitle:脱硫酸化与多硫酸化肝素衍生物对肥大细胞脱颗粒的影响
- Author:
Xueqiang FAN
;
Shengli JI
;
Yanqing CHI
;
Jichao CAO
;
- Publication Type:Journal Article
- Keywords:
desulfated heparin;
poly sulfated heparin;
mast cell;
degranulation
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study effects of desulfated and poly sulfated heparin derivatives on rat mast cell (MC) degranulation. METHODS Different methods were used to prepare different sulfated heparin derivatives: 2 O desulfated heparin (2DeSH),N desulfated reacetylated heparin (NDeSAcH),6 O desulfated heparin (6DeSH),poly sulfated heparin (PSH). Passive MC degranulation induced by ovalbumin in rats to was employed observe the effects of different sulfated derivatives on rats MC degranulation. RESULTS All the sample groups were found of obvious inhibition of MC degranulation( P
