Protective effect of rosiglitazone on diabetic rat kidney
- VernacularTitle:罗格列酮对糖尿病大鼠肾保护机制的研究
- Author:
Zhangsuo LIU
;
Hongxin NIU
;
Genyang CHENG
;
Janhui LI
;
Jie SONG
;
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Peroxisome proliferator activated receptor gamma;
Rosiglitazone
- From:
Chinese Journal of Nephrology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of renal protective effect of rosiglitazone on diabetic rat kidney. Methods Eighteen rats were assigned to normal control(C) group,diabetic rat(DM) group, rosiglitazone(5 mg?kg-1?d-1)treatment(R) group.Immunohistochemistry,RT PCR,Western blot were used to examine the pathological change of kidney and expression of PPAR?、TGF ?1 after 8 weeks in the kidney of rats. Results In comparison with normal group, the expression of PPAR?and TGF ?1 in diabetic rat and treatment groups was markedly increased(P
