Detection of beta-catenin expression in colorectal adenoma and adenocarcinoma by tissue chips and its significance
- VernacularTitle:应用组织芯片检测结直肠腺瘤腺癌?-连环蛋白的表达及其意义
- Author:
Guangjie DUAN
;
Xiaochu YAN
;
Rong ZHANG
;
Limei LIU
;
- Publication Type:Journal Article
- Keywords:
tissue chip;
colorectal tumor;
catenin;
immunohistochemistry
- From:Journal of Third Military Medical University
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of ? catenin expression with the carcinogenesis and progression of human colorectal cancer Methods The colorectal adenoma carcinoma tissue chips including 400 cores were constructed and the expression of ? catenin in 220 cases of colorectal adenoma and carcinoma was detected by immunohistochemical staining Results The effective rates of information by tissue chips stained by hematoxylin eosin and immunohistochemistry were 98 8% and 98 0%, respectively The nuclear expression rate of ? catenin was 35 9% in malignant changes in adenoma, which was significantly higher than that in adenoma (16 7%) and carcinoma (19 7%) ( P
