Expressions of CD28 and CTLA-4 in peripheral blood and synovial fluid lymphocytes in patients with rheumatoid arthritis and the significance
- VernacularTitle:CD28/CTLA-4在类风湿关节炎患者外周血和关节积液中的表达及意义
- Author:
Jingyi LI
;
Yuzhang WU
;
Yongfei FANG
;
Yong WANG
;
Jingbo ZHANG
;
Yang LI
;
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
activation of T cell;
co stimulatory signal;
CD28;
CTLA 4
- From:Journal of Third Military Medical University
1988;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of co stimulatory factors CD28 and CTLA 4 on CD3 + T cells in peripheral blood lymphocytes (PBMC) and synovial fluid lymphocytes (SFMC) in patients with rheumatoid arthritis (RA) and the relationship of these molecules with the activity of RA. Methods The lymphocytes were collected from the peripheral blood and synovial fluid in RA patients. The CD3 +CD28 + and CD3 +CTLA 4 + molecules on these cells were measured by dual color fluorescence cytometry. The correlation of the expressions of CD3+CD28+ and CD3 +CTLA 4 + molecules with the activity of RA was statistically analyzed by Spearman. Results ① The level of CD3 +CD28 + in PBMC of RA patients was significantly lower than that of the control group and SFMC ( P
