Progress of caspase inhibitors in pharmacology
- VernacularTitle:Caspase抑制剂的若干药理学研究进展
- Author:
Hongtao ZHANG
;
Shoujun YUAN
;
Zhengqiang LI
;
- Publication Type:Journal Article
- Keywords:
apoptosis;
caspase;
inhibitor;
cytoprotection
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Apoptosis is involved in a variety of diseases. Cysteine aspartate specific protease (caspase), a protease family which executes apoptosis, plays a crucial role in course of apoptosis. It can be activated through various pathways. Some natural and synthetic caspase inhibitors will strengthen anti apoptotic action through inhibiting one or several caspase activity, and will become effective means in treating diseases caused by overapoptosis.
