Therapeutic effects of rhein on experimental diabetic nephropathy in rats
- VernacularTitle:大黄酸治疗大鼠糖尿病肾病的实验研究
- Author:
Zhihua AI
;
Hongwei CAI
;
Zhonghui ZHANG
;
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
endothelin;
rhein
- From:Journal of Third Military Medical University
1983;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effects of rhein on experimental diabetic nephropathy in rats. Methods Rat model of diabetic mellitus was established by interperitoneal injection of streptozotocin (50 mg/kg) . Renal damages and changes of endothelin (ET) in urine and renal tissues were observed at 12 weeks after the induction of diabetic mellitus and after treatment with rhein (70 mg/kg). Results Compared with the normal rats, at 12 weeks after hyperglycemia, diabetic rats had decreased renal weight/body weight(RW/BW), significantly increased mean glomerular plane area (MGPA), mean glomerular volume (MGV), creatinine clearance rate (Ccr), blood urea nitrogen (BUN), and 24 hour urinary protein excretion (UPE) ( P
