Single nucleotide polymorphism in studying complex diseases susceptibility gene
- VernacularTitle:单核苷酸多态性在复杂性状疾病易感基因研究中的应用
- Author:
Ruiwen CHEN
;
Shuhan SUN
;
- Publication Type:Journal Article
- Keywords:
single nucleotide polymorphisms;
complex diseases;
susceptibility gene
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Most diseases are complex genetic traits caused by multiple genetic and environmental components. It has been proposed that common genetic variations, mainly single nucleotide polymorphisms (SNPs), influence the susceptibility to complex diseases. We have conducted an extensive review on the characters of SNPs, the related website information, and the genotyping methods of SNPs such as direct sequencing, SnaPshot, Taqman, real time quantitative (kinetic) PCR with allele specific amplification, denaturing high performance liquid chromatography, and OLA/PCR.The strategies for studying the relation between SNPs and complex diseases susceptible genes were also reviewed.
