Fluvastatin inhibiting proliferation of rat lung fibroblasts
- VernacularTitle:氟伐他汀对大鼠肺成纤维细胞增殖的抑制作用
- Author:
Feng ZHAO
;
Haowen QI
;
Jiangfeng YE
;
- Publication Type:Journal Article
- Keywords:
fluvastatin;
lung;
fibroblast;
cell proliferation;
inhibition
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the inhibitory effect of fluvastatin (Flu) on the proliferation of the rat lung fibroblasts cultured in vitro . Methods: Normal rat lung derived fibroblasts were cultured in media containing Flu. The influences of Flu on the growth curve of the fibroblasts were observed by cell count and MTT colorimetry. The inhibition effect of Flu serial dilutions on the fibroblasts proliferation was investigated. Influence of Flu on division index of the fibroblasts was analyzed by direct cell count. Chemical colorimetry was used to detect the hydroxyproline in the media. Results: Flu inhibited the proliferation of the normal rat lung fibroblasts in the manner of dose dependence( P
