Negative feedback regulation of TGF-?/Smad signaling pathway by Smad7 in renal fibrosis
- VernacularTitle:Smad7对TGF-?/Smad信号转导通路的调节及其在肾纤维化中的作用
- Author:
Lin WANG
;
Yueyi DENG
;
Yiping CHEN
;
- Publication Type:Journal Article
- Keywords:
Smad;
transforming growth factor ?;
signal transduction;
renal fibrosis
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
TGF ? plays a crucial role in the renal fibrosis and Smads mediate the intracellular signal transduction of TGF ?.Overexpression of Smad7,which can mediate TGF ? by the feedback action,is able to change the physiopathology equilibrium between the R Smads response and the I Smads inhibition to the fibrosis induced by TGF ?.It may help to understand the mechanism of renal fibrosis and Smads TGF ? signaling transduction, and it may also provide a new approach to the renal fibrosis.
