Effect of vascular endothelial growth factor on angiogenesis and its regulation
- VernacularTitle:血管内皮生长因子促血管形成作用及其调控
- Author:
Jianhua WANG
;
Qingshui YIN
;
Qingchun HUANG
;
Yuesong WU
;
- Publication Type:Journal Article
- Keywords:
vascular endothelial growth factor;
angiogenesis;
review literature
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Vascular endothelial growth factor(VEGF) is a kind of protein facilitating the angiogenesis,which can combine with its special receptor. The 2 major functions of VEGF are:(1) accelerate the proliferation of endothelial cells,leading to the formation of new vessels;(2) up regulation of the vessels permeability.The activity of the VEGF is regulated by various factors at different levels,such as: hypoxia, oncogene,the cytokine, the intercellular matrix, etc .The biological character and role of VEGF were summarized in this article with special emphasis on VEGF function and regulation.
