Pharmacokinetics of honokiol in rats
- VernacularTitle:和厚朴酚在大鼠体内的药代动力学研究
- Author:
Shizhong CHEN
;
Hui JIA
;
Yaohua WU
;
Hong WANG
;
- Publication Type:Journal Article
- Keywords:
Magnolia officinalis;
Honokiol;
Pharmacokinetics;
Dosage forms
- From:
Journal of Peking University(Health Sciences)
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the pharmacokinetics of honokiol in rats. Methods: Honokiol injection was delivered by vein injection to SD rats. The blood samples were gathered at a series of time lags. Honokiol in rat plasma was determined with an RP HPLC method and the data were analyzed with program 3P87. Results: After i v injection of honokiol, concentration time curves were fitted to a 3 compartment model: with halftime of 2.8 min, 11.9 min, and 56.8 min. Conclusion: Honokiol was quickly distributed in rats after i.v. and the concentration decreased rapidly. Our studies provided important referrence to the research on the pharmacodynamics and the pharmaceutics of Honokiol.
