Effect of naloxone on remote seizure susceptibility
- VernacularTitle:纳洛酮对幼年大鼠反复热惊厥后远期惊厥易感性的影响
- Author:
Ying SHAN
;
Jiong QIN
;
Xingzhi CHANG
;
Zhixian YANG
;
- Publication Type:Journal Article
- Keywords:
Naloxone;
Seizures,febrile;
Hippocampus/pathol;
Rats
- From:
Journal of Peking University(Health Sciences)
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective : To evaluate the effect of low dose naloxone on remote seizure susceptibility after repeated febrile seizures(FS) in developing age. Methods: Warm water induced rat FS model was developed in this study.Forty nine SD rats were randomly divided into two groups: normal control group( n =10) and hyperthermic seizure group( n =39).The latter was further divided into FS control group( n =13) and naloxone treated group( n =26). The dose of naloxone was different in the two naloxone treated groups(13/each group). One group dose was 1 mg/kg, and the other 2 mg/kg. Each rat of hyperthermic seizure groups was induced to have 7 febrile seizures at the interval of 1 day. The rats were weighed and injected intraperitoneally with naloxone once the FS occurred in naloxone treated group, while the rats of other groups were injected with 0.9% sodium chloride. After the seventh stimulation, all rats were left un stimulated for 2 months, then re stimulated. Re stimulated seizureincidence rate, seizure duration and seizure grade in different groups were observed and compared with each other. Hippocampal mossy fiber sprouting was detected by Timm stain. Results: In naloxone treated group, the rats'seizure duration and seizure grade [(5.66?2.78) min,(2.97? 1.18)] significantly decreased ( t =5.035, P
