Human telomerase,P53, estrogen and progesterore receptor expression in endometrial carcinoma
- VernacularTitle:子宫内膜癌中端粒酶与c-myc基因、P53蛋白和激素受体表达及相关性
- Author:
Ying DONG
;
Ting LI
;
Ying LIANG
;
Wanzhong ZOU
;
- Publication Type:Journal Article
- Keywords:
Endometrial neoplasms;
Telomerase;
Genes,myc;
Protein P53;
Recepters,estrogen;
Reuptors,progesterone
- From:
Journal of Peking University(Health Sciences)
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the role of hTERT and c myc, P53, ER, PR in endometrial carcinoma carcinogenesis. Methods: The expression of hTERT, c myc mRNA, P53 protein, ER and PR examined by in situ hybridization and immunohistochemistry in 14 cases of endometrial simple hyperplasia, 10 of complex hyperplasia, 8 of atypical hyperplasia and 52 with endometrial carcinoma. Results: (1) The positve rate of hTERT in simple, complex, atypical hyperlasia and carcinoma were 14.3% (2/14), 50.0% (4/8), 80.0% (8/10) and 92.3% (48/52), respectively. The prevalence and intensity of hTERT signal were greater in the carcinomas and atypical hyperplasia than those in simple or complex hyperplasia (P
