Tetrasomy 8 in a Patient with Acute Monoblastic Leukemia.
10.3343/kjlm.2008.28.4.262
- Author:
Juwon KIM
1
;
Tae Sung PARK
;
Jaewoo SONG
;
Kyung A LEE
;
Sang Guk LEE
;
June Won CHEONG
;
Jong Rak CHOI
Author Information
1. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea. cjr0606@yuhs.ac
- Publication Type:Case Report
- Keywords:
Acute myelogenous leukemia;
Tetrasomy 8;
Poor prognosis
- MeSH:
*Aneuploidy;
*Chromosomes, Human, Pair 8;
Humans;
In Situ Hybridization, Fluorescence;
Karyotyping;
Leukemia, Monocytic, Acute/*diagnosis/genetics/pathology;
Male;
Middle Aged
- From:The Korean Journal of Laboratory Medicine
2008;28(4):262-266
- CountryRepublic of Korea
- Language:English
-
Abstract:
Trisomy 8 is one of the most frequent numerical chromosomal abnormalities observed in hematological malignancies, whereas tetrasomy 8 is a clonal aberration seen mainly in myeloid disorders such as acute myelod leukemia (AML) and myelodysplastic syndromes. In contrast to trisomy 8, tetrasomy 8 is a rare chromosomal aberration, in that only 17 reported AML cases with isolated tetrasomy 8 have been documented. Interestingly, the majority of reported cases were associated with monocytic-lineage leukemias. According to recent reports, tetrasomy 8 is regarded as a poor prognostic factor, and most patients having this abnormality relapsed and died within 1 yr. Here, we report a patient with acute monoblastic leukemia having tetrasomy 8 and a very aggressive disease course.
