Effect of ketamine on proliferation and the cell cycle of cultured rat neural stem cell
- VernacularTitle:氯胺酮对胚胎大鼠培养神经干细胞增殖和细胞周期的影响
- Author:
He HUANG
;
Tiande YANG
;
Hui YANG
;
Jun TAO
;
Yuewei WU
;
- Publication Type:Journal Article
- Keywords:
ketamine;
neural stem cell;
proliferation;
cell cycle
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effect of ketamine on proliferation,cell cycle in the cultured rat neural stem cells. METHODS The growth inhibition of ketamine on neural stem cell was evaluated by an MTT assay. The effect of ketamine on cell cycle was measured by flow cytometry. RESULTS Ketamine inhibited the growth of cultured rat neural stem cells. Flow cytometry analysis showed that G 0/G 1 phase rate was increased but S phase rate was decreased. CONCLUSION Ketamine can inhibit proliferation of cultured rat neural stem cells,and this inhibitition is associated with cell cycle block.
