The regulation of muscarinic receptor activated Kir3.1/3.4 currents by intracellular pH
- VernacularTitle:细胞内pH对胆碱能受体介导的Kir3.1/3.4电流的调节
- Author:
Xiaona DU
;
Chuan WANG
;
Qingzhong JIA
;
Hailin ZHANG
;
- Publication Type:Journal Article
- Keywords:
inward rectifier potassium channel Kir3.1/3.4;
intracellular pH;
M receptor
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Kir2 1. Moreover, drop of pHi reduced the M 1 induced inhibition of Kir3 1/3 4 currents, and enhanced the desensitization of M 2 induced Kir3 1/3 4 activation. CONCLUSION The basal currents and M receptor induced currents of Kir3 1/3 4 can be regulated by intracellular pH. These changes may play some important roles in pathophysiological conditions like cardiac ischemia.
