Estrogen inhibition on the expression of amyloid precursor protein C-terminal in ovariectomized female rat hippocampus and cortex
- VernacularTitle:雌激素抑制淀粉样蛋白前体羧基端片段在雌性去势大鼠海马和脑皮质的表达
- Author:
Min JIN
;
Hefeng HUANG
;
Fan JIN
;
- Publication Type:Journal Article
- Keywords:
amyloid precursor protein;
C terminal fragment;
premarin;
progynova;
hippocampus;
cortex
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effect of estrogen on the expression of amyloid precursor protein (APP) carboxyl terminal fragment in ovariectomized female rat hippocampus and cortex regions. METHODS Ovariectomized female rats were fed with Premarin or Progynova for 3 cycles before sacrificed. S P immunohistochemistry was performed to detect the APP C terminal fragment distribution, and semi quantitative H score was used to compare the expression. RESULTS APP C terminal fragment expression in both female rat hippocampus and cortex increased significantly after ovariectomy. Compared with ovariectomized control, C terminal fragment expression in the above regions decreased. It was even lower in progynova group than in premarin group. CONCLUSION Both premarin and progynova down regulate the APP C terminal expression in ovariectomized female rat hippocampus and cortex. The modulation of progynova is more effective.
