Experiment study on antiallergic effects of norstemizole
- VernacularTitle:诺司咪唑抗过敏作用的实验研究
- Author:
Changxiao LIU
;
Ruizhi WANG
;
Ning LIU
;
Jing LI
;
Xiaoxiang CHENG
;
- Publication Type:Journal Article
- Keywords:
norastemizol;
antiallergic;
histame phosphate;
isolated guinea pig ileum;
permeability
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the antiallerergic effects of norastemizole. METHODS: Antiallergic effects of norastemizole were study using rats and guinea pigs. RESULTS: Norastemizole(10 -9 -10 -8 mol?L -1 ) caused inhibition effect on the hisitamine induced contraction of isolated guinea pig ileum. Its IC 50 was 4.42 ?10 -9 mol?L -1 Norastemizole at oral doses of 0.1 , 0.5 , 1 mg?kg -1 , norastemizole caused a significant inhibition on the histamin phosphate induced shock in guinea pigs (P
