?-catenin expression and colorectal adenoma with canceration
- VernacularTitle:?-catenin蛋白表达与大肠腺瘤癌变的关系
- Author:
Yujun HE
;
Baohua LIU
;
Debing XIANG
;
- Publication Type:Journal Article
- Keywords:
colorectal adenoma;
? catenin;
immunohistochemistry
- From:Journal of Third Military Medical University
1984;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between ? catenin expression and colorectal adenoma with canceration. Methods The expression levels of ? catenin in 25 cases of normal colorectal mucosa (NCM), 42 cases of colorectal adenoma (CA), and 19 cases of colorectal adenoma with canceration (CAC) were detected by immunohistochemistry. Results ? catenin expression was detected on the cell membrane in normal colorectal mucosa. Reduced membrane expression, cytoplasmic and nuclear expression were detected in the colorectal adenoma and adenoma with canceration. The cytoplasmic and nuclear expression rate of ? catenin was 89.5% in colorectal adenoma with canceration, significantly higher than that in colorectal adenoma(42 9%, P
