Laminin and fibronectin expressions in atypical hyperplasia and breast cancer and the significance
- VernacularTitle:乳腺不典型增生及乳腺癌中层粘连蛋白及纤维连接蛋白的表达及意义
- Author:
Xiaorong HAN
;
Jun JIANG
;
Hongmin MA
;
- Publication Type:Journal Article
- Keywords:
atypical hyperplasia;
breast neoplasm;
laminin;
fibronectin
- From:Journal of Third Military Medical University
2003;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of laminin(LN) and fibronectin(FN) expressions in atypical hyperplasia and breast cancer. Methods LN and FN expressions in normal breast tissue, tissues from grade Ⅰ, Ⅱ and Ⅲ atypical hyperplasia and breast cancer were detected by means of S P immunohistochemical staining method. Results In normal breast tissue, LN expression was found only in basement membrane, but FN expression in basement membrane and matrix. In gradeⅠ hyperplasia, LN expression was found in basement membrane and epithelium, but FN expression was similar to that in normal tissue. In grade Ⅱhyperplasia, more LN expression was found in epithelium, but FN expression in epithelium and matrix. In grade Ⅲ hyperplasia, LN expression increased significantly in matrix and decreased significantly in epithelium as compared with those in grade Ⅱ( P
