Changes of plasma levels of homocysteine and MCP-1 in patients with coronary artery disease
- VernacularTitle:冠心病患者血浆同型半胱氨酸与单核细胞趋化蛋白-1水平的变化
- Author:
Zhe ZHANG
;
Guang WANG
;
Yingbin XIAO
;
- Publication Type:Journal Article
- Keywords:
homocysteine;
MCP 1;
atherosclerosis
- From:Journal of Third Military Medical University
2003;0(23):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of plasma levels of homocysteine (Hcy) and monocyte chemoattract protein 1 (MCP 1) in coronary artery disease (CAD) patients and to analyze the effect of Hcy on the expression of MCP 1. Methods The CAD diagnosis of all the studied subjects was confirmed by coronary angiography. A total of 70 patients with CAD and 50 control subjects were recruited in the study. Plasma Hcy concentration, plasma malondialdehyde (MDA) and plasma MCP 1 were determined by high performance liquid chromatography (HPLC), standard protocols and ELISA, respectively. Results Plasma levels of Hcy, MDA and MCP 1 in patients with CAD were significantly higher than those in the control subjects ( P
