Effects of recombinant endostatin on the growth and angiogenesis of mouse bladder cancer
- VernacularTitle:重组endostatin抑制小鼠膀胱癌生长及血管形成研究
- Author:
Jinhong PAN
;
Liang WANG
;
Xiyu JIN
;
Bo SONG
;
- Publication Type:Journal Article
- Keywords:
endostatin;
angiogenesis;
bladder cancer
- From:Journal of Third Military Medical University
2003;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the inhibitory effect of endogenous angiogenesis inhibitor endostatin on the growth of bladder transitional cell carcinoma. Methods Recombinant mouse endostatin expressed by E. coli was purified with Ni NTA affinity chromatography and was administrated into mice bearing T739 bladder transitional cell carcinoma via subcutaneous injection at the dose of 20 mg?kg -1 ?d -1 . The tumor growth and angiogenesis were observed 10 days later. Results Tumors in mice treated with endostatin grew slowly and the inhibition rate reached 81 4%. Microvessel density(MVD) of tumor in treated group was significantly lower than that in the control group( P
