COMPARISON AND ANALYSIS OF THE INFLUENCE OF DIFFERENT STIMULATING FACTORS ON PROTEIN METABOLISM OF RAT SKELETAL MUSCLE
- VernacularTitle:不同因素刺激对大鼠骨骼肌组织蛋白代谢影响的比较与分析
- Author:
Yanqiu WU
;
Jiake CHAI
;
Hongming YANG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
muscle, skeleton;
protein;
metabolism;
burn;
sepsis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of different stimulating factors on protein metabolism of rat skeletal muscle. Methods Three kinds of animal models were used in this study as follows: burn injury group (group B, n =40), endotoxin challenge group (group E, n =40), and burn injury followed by endotoxin challenge group (group B+E, n =40). The proteolytic rate of extensor digitorium longus (EDL) muscle was determined by amino acid auto analyzer after incubation in a muscle incubation system. Results The proteolytic rate of EDL muscle of rats was increased markedly in those three groups, especially the myofibrillar proteolytic rate. The protein breakdown of muscle in group E was higher than that of group B, and it was even much higher in group B+E. Conclusions As compared among burn injury, endotoxin challenge and burn injury followed by endotoxin challenge, the change in muscle proteolytic rate is correlated to seriousness of the injuries
