MOLECULAR MECHANISM UNDERLYING DEVELOPMENT OF HELICOBACTER PYLORI-RELATED GASTRIC CANCER
- VernacularTitle:幽门螺杆菌致胃黏膜癌变的分子机制
- Author:
Dianchun FANG
;
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
stomach neoplasms;
molecular mechanism
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Helicobacter pylori ( H.pylori )infection is an important aetiological risk factor of gastric cancer, and has been classified as group I or definite carcinogen by the World Health Organization. The molecular mechanism of H.pylori leading to gastric cancer is still unclear. It has been increasingly recognized that cell proliferation and appoptosis,telomerase activition, genetic instability and abnormal DNA methylation are involved in the development of H.pylori related gastric cancer and its precursors. To better understand the pathogenesis of gastric cancer, a revie of the role of H.pylori infections in the induction of molecular events in gastric epithelial cells is presented in this paper.
