HELICOBACTER PYLORI INFECTION IS NOT RELATED TO hMLH1 AND APC MUTATION AND PROMOTER METHYLATION IN GASTRIC CANCER
- VernacularTitle:幽门螺杆菌感染与hMLH1和APC基因突变及hMLH1甲基化异常的关系
- Author:
Dianchun FANG
;
Rongquan WANG
;
Shiming YANG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
Helicobacter pylori;
genes, hMLH1;
genes, APC;
mutation;
methylation
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
0 05). APC mutation was correlated with intestinal type of gastric cancer ( P 0 05). APC mutation was detected in all MSI Low or MSS, while no mutation was found in MSI H. Conclusion hMLH1 mutation and promoter methylation are involved in MSI pathway and APC mutation is involved in LOH pathway in gastric cancer. H pylori infection is not related to hMLH1, APC mutation and promoter methylation in gastric cancer.
