THE RELATIONSHIP BETWEEN METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM AND HELICOBACTER PYLORI INFECTION IN GASTRIC CANCER
- VernacularTitle:胃癌亚甲基四氢叶酸还原酶基因677CT多态性与幽门螺杆菌感染的关系
- Author:
Peiren SI
;
Dianchun FANG
;
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
Helicobacter pylori;
methylenetetrahydrofolate reductase;
genes;
polymorphism
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
0 05). The individuals with 677CT and 677CT+TT genotypes had a 0 21 fold [95% confidence interval(CI), 0 43 0 99] and 0 26 fold (95%CI,0 07 0 98) reduced risk of developing gastric cardia cancer compared with those with 677CC genotype. The individuals with 677TT genotype had a 3 63 fold (95%CI,1 04 12 72) increased risk of developing gastric corpus cancer. MTHFR 677CT polymorphism was not correlated with H.pylori infection in gastric cancer. Conclusion The polymorphism of MTHFR 677CT is associated with increased risk of gastric corpus cancer and reduced risk of gastric cardia cancer, but not with H.pylori infection
