MITOCHONDRIAL DNA MICROSATELLITE INSTABILITY AND EXPRESSION OF Bcl-2 AND Bax mRNA IN GASTRIC CANCER AND ITS PRECANCEROUS LESIONS
- VernacularTitle:胃癌组织线粒体基因组不稳定与Bcl-2和BaxmRNA表达的关系
- Author:
Dianchun FANG
;
Xianlong LING
;
Yuanhui LUO
;
- Publication Type:Journal Article
- Keywords:
DNA, mitochondrial;
genes, Bcl 2;
genes, Bax gene expression;
stomach neoplasms
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between mitochondrial DNA microsatellite instability(mtMSI) and expression of Bcl 2 and Bax mRNA in gastric cancer and its precancerous lesions. Methods mtMSI and expressions of Bcl 2 and Bax mRNA were detected with PCR SSCP and RT PCR. Results Expressions of Bcl 2 mRNA in intestinal metaplasia (IM,53 3%) and dysplasia (Dys, 70%) were significantly higher than that in normal control(10%, P
