INDUCTION OF INTESTINAL METAPLASIA AND DYSPLASIA IN MONGOLIAN GERBILS INFECTED WITH HELICOBACTER PYLORI
- VernacularTitle:幽门螺杆菌感染诱发蒙古沙鼠胃黏膜肠上皮化生和异型增生
- Author:
Chunhui LAN
;
Yuanzhi ZHANG
;
Dianchun FANG
;
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
stomach neoplasms;
chemoprevention;
N methyl N’ nitro N nitrosoguanidine (MNNG);
vitamin C
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Using a model of H.pylori infected Mongolian gerbil , we observed the effect of H.pylori and N methyl N’ nitro N nitrosoguanidine (MNNG) on gastric mucosa, in an attempt to clarify the potential role of vitamin C in the prevention of gastric carcinoma. Methods A total of 160 Mongolian gerbils , eight week old, were randomly divided into five groups(each 32 animals): Group A, infected with H.pylori ; Group B, infected with H.pylori followed by MNNG administration; Group C, received MNNG without H.pylori infection; Group D, infected with H pylori followed by administration of MNNG and vitamin C; Group E as control. Eight animals from each group were killed at 12, 24, 36, 48 weeks, and histopathological changes in their stomachs were examined for chronic gastritis, intestinal metaplasia, atypical hyperplasia and adenoma. Results The incidences of intestinal metaplasia and dysplasia in groups A and B were significantly higher than those in the other groups( P
