DYNAMIC CHANGES IN PERIPHERAL BLOOD LYMPHOCYTE AND PLASMA CYTOKINE LEVELS IN PATIENTS WITH SEVERE ACUTE RESPIRATORY SYNDROME (SARS)
- VernacularTitle:严重急性呼吸综合征患者细胞因子和外周血淋巴细胞的动态变化
- Author:
Min WANG
;
Fusheng WANG
;
Dongping XU
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
severe acute respiratory syndrome (SARS);
cell factor;
lymphocytes enzyme linked immunosorbent assay (ELISA)
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the immunological status of patients with SARS by monitoring the dynamic changes in peripheral blood lymphocyte count and plasma levels of cytokines. Methods Levels of IFN ?,TNF ?, IFN ?, IL 12 and IL 10 in plasma of 21 SARS patients were sequentially assayed with enzyme linked immunosorbent assay (ELISA) Lymphocyte count of peripheral blood was also determined. Results Peripheral blood lymphocyte counts in 66 7% of patients, plasma IFN ? level in 38 1% of patients, and plasma TNF ? level in 61 9% of patients showed inverted V shaped profiles, with peaks in the middle of SARS course. Production of Th2 cytokine IL 10 was not influenced in the present study in all patients, while high levels of Th1 cytokines IL 12 and IFN ? were observed during the observation period in some patients. The first detected values of IFN ?. In 85 7% of patients, the levels of IFN ? at the onset of symptoms were much lower than those in normal controls (867 18?306 50pg/ml; P
