Roles of epithelial CTGF expression in airway remodeling in asthmatic rats
- VernacularTitle:哮喘大鼠气道上皮CTGF表达及其与气道重构关系的研究
- Author:
Guoxiang LIU
;
Lei ZHANG
;
Ying HUANG
;
- Publication Type:Journal Article
- Keywords:
asthma;
CTGF;
airway remodeling
- From:Journal of Third Military Medical University
2003;0(20):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the roles of connective tissue growth factor(CTGF) in airway remodeling in asthmatic rats by observation of the changes of CTGF expression in the lungs of asthmatic rats. Methods Rats were sensitized and challenged continually with ovalbumin(OVA) for the purpose of induction of asthma in rats. The distribution and types of collagens were detected by Cirius red staining. Lung hydroxyproline content was determined by acid hydrolysis. CTGF expression in rat pulmonary tissues was detected by SABC immunohistochemistry. Results After continual challenging with OVA for 21 days, collagen hyperplasia was found in the airway wall and CTGF positive expression in airway epithelium. CTGF expression was closely associated with lung hydroxyproline content ( r =0.63, P
