Mechanism of celluar import mediated by nuclear localization signals
- VernacularTitle:核定位信号介导的细胞转运及其机制
- Author:
Ailing FU
;
Manji SUN
;
- Publication Type:Journal Article
- Keywords:
NLS, celluar uptake, mechanism
- From:
Chinese Pharmacological Bulletin
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Some basic nuclear localization signals(NLS) have the capability of penetrating cell membrane and deliverying recombinant proteins, DNA, oligonucleotide into living cells. NLS based delivery system prohaps can satisfy most of major requirement in cargoing exogenous macromolecules or charged compounds. Different internalization mechanisms were found for different NLSs. Endocytosis or electrostatic binding of the anionic membranes and cationic NLSs probably induce celluar uptake.
